![]() ![]() ![]() Blood drains into the branch of the hepatic vein that lies in the lobule's center via sinusoidal lumens of the lobule. This makes sense as the liver produces bile, so bile in the ducts are leaving the liver whereas, the dual blood supply is entering the liver to perfuse it. It is important to recognize that bile and blood flow in opposite directions to each other. Due to the 3-dimensional arrangements of hepatocytes, the canaliculi form a lattice-like network or “chicken-wire pattern,” that helps increase the surface area of flow. It plays the largest role in detoxification, biotransformation of drugs, ketogenesis, glycolysis, lipogenesis, glycogen synthesis, and glutamine formation.īile flow is further facilitated by bile canaliculi, which are formed by apical membranes of neighboring hepatocytes. Zone III has the lowest perfusion due to its distance from the portal triad. ![]()
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